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apalutamide will decrease the extent or influence of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with drugs which can be CYP3A4 substrates may lead to decreased exposure to these drugs.As always, even so, often do not forget that